Microbiome Gut flora Leaky gut Histamine Zonulin Digestion

Gut and microbiome

Stool and breath tests you do at home. They measure bacterial composition, yeasts and fungi, digestive performance, barrier function and inflammation markers in the gut — with the laboratory's reference range for every value.

You collect the sample yourself; no blood is needed. Stool and urine analyses usually take 7 to 21 days from the arrival of the sample. Every analysis includes a free results consultation.

Sample at homeStool, urine or breath7 to 21 days from sample arrivalResults consultation includedPartner laboratory in Germany
Erreger

Parasites and worms

After travelling, or with persistent symptoms and nothing found. Results belong in a doctor's hands.

2 tests · €125 to €150.50
Vorsorge

Darmvorsorge

The Colosafe test adds to the statutory bowel cancer screening, it does not replace it. Colonoscopy remains the standard.

1 test · €275
Marker

What a stool analysis can measure

Which of these markers are included is stated on each product page. No test includes them all.

Bereich Marker What the value tells you
Microbiome Bifidobacteria, lactobacilli, Bacteroides, clostridia Composition and relative amounts of the gut bacteria compared with the reference range.
Yeasts and fungi Candida, Geotrichum Amount of yeast in the stool. Small amounts are normal — in many people yeasts are part of the gut flora.
Stool environment pH value, consistency Whether the gut environment is acidic or alkaline; pointers to transit time.
Digestive performance Fat, nitrogen, sugar in the stool Residues in the stool show how completely food components were broken down and taken up.
Enzymes Pancreatic elastase, bile acids Whether pancreatic digestive enzymes and bile acids are present in the expected amounts.
Barrier Zonulin, alpha-1 antitrypsin Markers involved in regulating the tight junctions between the gut epithelial cells.
Inflammation Calprotectin A pointer to inflammatory processes in the gut lining. A raised value should be checked by a doctor.
Mucosal immunity Secretory IgA (sIgA) An antibody of the gut lining involved in regulating contact between the immune system and the microbiome.

A value outside the reference range is a pointer, not a diagnosis. What it means in your situation is something for the results consultation and for your doctor.

Studienlage

The evidence on the four most common questions

Barrier, histamine, yeasts and microbiome are the areas people ask about most. For all four the research is mixed — that belongs in the answer, not in the small print.

Gut barrier · leaky gutZonulin and absorptionLimited evidence
Zonulin as a marker of tight junctions described
Zonulin is regarded as the only physiological modulator of tight junctions described so far.
Guide values for zonulin in stool indicative
Evidence on measuring it in stool is limited; the specialist literature treats the guide values used as rough orientation only.
Cause or consequence open
Whether increased permeability is the cause or the consequence of a disease is still being researched.

Raised zonulin values have been found in coeliac disease, type 1 diabetes and inflammatory conditions. In coeliac disease they fall on a gluten-free diet, in step with the inflammation markers. Critics regard the measurement as questionable outside an established gastroenterological condition.

What that means for the test: The value tracks change over time; it is not a diagnosis. “Leaky gut” is not an established diagnosis, and we use the term only as a product name.
Fasano 2011 · Literature review on leaky gut, Ostendorf, Der Medizinische Sachverständige 2018
Histamine · DAOWhat DAO testing can doGuideline: no diagnostic value
Frequency of histamine intolerance around 1 %
A French study puts it at about one per cent of the population, mostly women. This figure does not come from the guideline.
DAO activity in blood as a diagnosis not informative
The guideline states word for word: “Diagnosis based on measuring DAO enzyme activity in blood is not informative.”
Conclusions about the small intestine not possible
On current knowledge, DAO activity in human blood allows no conclusions about enzyme activity in the small intestine.

Studies in affected people and healthy controls suggest that the blood values are comparable. Using DAO-specific antibodies, DAO could not be detected in any notable amount in serum, but was found in kidney, gut and placenta. Copper, vitamin B6 and vitamin C are cofactors of the enzyme; alcohol, smoking and certain medicines inhibit it.

What that means for the test: The blood value neither proves nor rules anything out. The guideline reaches the diagnosis through a three-stage change of diet: 10 to 14 days of avoidance, then a test phase of up to six weeks, then a long-term diet — supported by a doctor or dietitian, not by a lab value.
AWMF guideline 061-030, March 2022 version · DGAKI, GPA, AeDA, SGAI and ÖGAI · wording checked in the guideline on 23 August 2026
Yeasts and fungi · CandidaWhat a Candida finding meansA finding is not a diagnosis
Candida in the stool of healthy adults 20 to 80 %
Depending on the detection method, sample collection and transport time. In many people yeasts are part of the normal gut flora.
A finding alone as a sign of illness no
Anyone who feels well and is found to have Candida needs no treatment. Testing without symptoms makes little sense.
Anti-fungal diet as an evidenced therapy not evidenced
A specific anti-Candida effect of a diet is not scientifically established; professional societies do not recommend it as standard therapy.

In the gut, Candida lives in the lumen and — unlike in the mouth or genital area — usually does not penetrate the lining. It becomes serious when the immune system is severely weakened, for example during chemotherapy or after a transplant; treatment then belongs in medical hands. The so-called “Candida syndrome”, offered as an explanation for a wide range of non-specific symptoms, is not an established diagnosis.

What that means for the test: The value belongs in the overall picture, not on a sheet of its own. That is why we do not offer a separate Candida test — yeasts and fungi are measured within the microbiome profiles.
S1 guideline 082/005 “Diagnosis and treatment of Candida infections”, DMykG and PEG, 2020 version — it has since expired, an update is under way.
Microbiome · diversityDiversity and what it tells youLink evidenced, measurement inconsistent
Recovery after last-line antibiotics 6 months
In twelve healthy men the microbiome had almost fully recovered after six months — a few sensitive species stayed gone for good.
Species lost after clindamycin −47 species
Effects of clindamycin, fluoroquinolones (−20) and flucloxacillin (−21) were in part still measurable years later. Amoxicillin showed no long-term effect.
Valid clinical diversity index missing
No diversity index captures every aspect, and the function of the microbiome is left out of the picture.

High diversity is regarded as favourable because it makes functional redundancy more likely: key tasks still get done when something is disturbed. Valid clinical biomarkers for assessing dysbiosis diagnostically are still missing.

What that means for the test: A microbiome report describes a state; it does not make a diagnosis. It becomes useful over time: a second measurement after a few months shows whether anything has shifted.
Palleja et al. 2018, twelve healthy men · reviews of antibiotic effects on the microbiome
Why we offer it anyway

A measured value with a reference range is more than a guess, even if on its own it is not a diagnosis. It becomes the starting point for a conversation and for a second measurement a few months later. That is why every analysis here comes with a results consultation — and why this page also says what a value cannot do.

Initial consultation
Ablauf

From kit to results consultation

  1. 01 Kit arrives or collect it Dispatch the next working day, or collection at the practice in Berlin.
  2. 02 Collect the sample at home Instructions are included. Please read them first — some tests have rules about food or medication.
  3. 03 Send it in Return envelope included, postage within Germany is paid. Post it Monday to Thursday.
  4. 04 Lab report and consultation 7 to 21 days from the arrival of the sample. The results consultation by phone or at the practice is included, and you book the time.

Whether one of these is right for you is something for the results consultation. This page recommends nothing.

Food supplements are not a substitute for a balanced, varied diet and a healthy lifestyle.

Do I need a doctor for this?

No. The test set comes by post, or you collect it at the practice, and you take the sample at home. If you are not sure which set fits your question, we sort that out in the free initial consultation.

Does this replace seeing a doctor?

No. Acute or persistent symptoms belong in a medical practice. The results can be helpful for further investigation; they do not take its place.

Is there a standalone Candida or fungal test?

No, and there is a reason: yeasts are found in the stool of 20 to 80 per cent of healthy adults. A finding on its own therefore says little. Candida and Geotrichum are measured within the microbiome profiles — there the value sits alongside the rest of the flora and can be interpreted.

Anything to note when collecting the sample?

Yes. Each test set has its own instructions, some with rules about food, antibiotics or probiotics in the days before. Read them before you collect the sample.

How long until the result?

The evaluation takes 7 to 21 days from the arrival of the sample at the laboratory — not from the order. Exactly how long depends on the method: sequencing the gut flora takes longer than a measurement from capillary blood.

Do I get help understanding the results?

Yes, every analysis includes a free results consultation, by phone or at the practice. You book the appointment by phone or email.

Can I order a test for someone else?

Yes. The request form must carry the details of the person being tested: name, date of birth and phone number. Please correct anything already entered.

Which analysis fits my question?

If the question is open, a profile covers several areas. If it is narrowed down — histamine, gluten, small intestine, parasites — a single test is usually enough. The list at the top of this page is sorted by symptom.

When should I see a doctor at once?

If you see blood in your stool, black stool, unintended weight loss, fever or severe persistent pain. Signs like these belong with a doctor, not with a self-test.

Your Partner in Health

These analyses do not replace medical assessment or bowel cancer screening. With blood in the stool, unintended weight loss, fever or persistent severe pain, go straight to a doctor.