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Ageing well

From about fifty onwards, the body loses one to two per cent of its muscle mass every year. That is normal. Whether that comes to a quarter less in twenty years or to considerably more is settled by things that can be measured before strength starts to fail.

Nutrients, amino acids, inflammatory values, hormones and messenger substances change earlier than strength does — and can be measured at home from a single sample.

Analysen

What is measured here

9 Analysen · €75 bis €354,94
Whole Blood Mineral Analysis – Figure 1 of 5 Kapillarblut
VollblutmineralanalyseMinerals inside the cell rather than in serum alone — zinc, selenium, iron, copper and magnesium.
intrazellulärEinstieg
€75,00 Ansehen
Vitamin Check Basic – Figure 1 of 3 Kapillarblut
Vitamin Check BasicVitamin D, B12, E, folic acid and coenzyme Q10 — the vitamins whose supply most often falls off with age.
Vitamin DB12Q10
€98,50 Ansehen
Daily Cortisol Profile – Figure 1 of 5 Speichel
Cortisol-TagesprofilCortisol in the morning, at midday and in the evening, plus DHEA. If the evening value stays high, sleep shifts towards the lighter stages.
3 MesspunkteDHEA
€155,00 Ansehen
Neurotransmitter Plus – Figure 1 of 3 Urin
Neurotransmitters plusSerotonin, dopamine, GABA and the breakdown products — the chain that ends in melatonin, and with it deep sleep.
SerotoninGABADopamin
€185,90 Ansehen
OM Vital Blood Test – Figure 1 of 3 Kapillarblut
OM VitalVitamin B12, homocysteine and folic acid together with hs-CRP, ferritin, selenium, zinc and Q10.
B12Homocysteinhs-CRP
€205,00 Ansehen
Organic acid – Figure 1 of 3 Urin
Organic acidsUp to 22 metabolic markers, among them methylmalonic acid — the value that shows whether B12 is reaching the cell.
Methylmalonic acidup to 22 markers
€205,00 Ansehen
Intestinal profile microbiome, leaky gut mucosa check – Figure 1 of 5 Stuhl
Gut microbiome analysisComposition and diversity of the gut flora, digestive performance and the markers of the gut lining.
Microbiomezonulin7–21 days
€315,00 Ansehen
Prevent 360 – Figure 1 of 5 Kapillarblut
Prevent 36075 values across six areas, including 18 amino acids with leucine. The broad stocktake.
75 Werte120 µl
€325,00 Ansehen
Epigenetics | Stress Monitor – Figure 2 of 2 Kapillarblut
Epigenetics · healthy ageingDNA stability, inflammation factors, micronutrients and stress-associated miRNAs. Gives no age figure.
DNA-StabilitätmiRNA
€354,94 Ansehen
Einstieg

One sample, six areas

Prevent 360 measures 75 values from 120 microlitres of capillary blood — nutrients, amino acids including leucine, inflammatory and metabolic markers, hormones and messenger substances. As a stocktake it covers the four areas this page is about, without you having to pick a direction first.

Nutrientsamino acidsinflammationmetabolism and blood lipidshormonesneurotransmitters
View Prevent 360 · €325,00
Prevent 360 – Figure 1 of 5
Figure 1 · Muscle over time

One to two per cent a year — and what that comes to in twenty years

The loss starts gradually and goes unnoticed for a long time, because everyday movement needs little strength. By the time a flight of stairs or a full shopping bag becomes a problem, a lot has already gone.

0 % 25 % 50 % 75 % 100 % 100 % rund 74 % 50 Jahre 55 Jahre 60 Jahre 65 Jahre 70 JahreShare of muscle mass compared with the level at 50 The axis runs from 0 to 100 per cent: counting from the age of 50, the average person still has around three quarters of their muscle mass at 70 — the loss is noticeable, but the curve stays in the upper quarter. Calculated at 1.5 per cent a year, the middle of the range given. This is an average and not a prediction for any one person; exercise, diet and illness shift it in both directions — upwards as well as downwards.
1 to 2 % of muscle mass a year from 50 Plus about 1.5 per cent of muscle strength a year. In some people the loss goes beyond this — that is called sarcopenia.Pharmazeutische Zeitung, review of sarcopenia
7 % sarcopenia in the over-65s in Germany From the population study KORA-Age: 8.8 per cent in women, 5.2 per cent in men. Worldwide the figures range from 10 to 27 per cent in the over-60s, depending on the definition.Deutsches Ärzteblatt 2025, KORA-Age
one third of care home residents with above-average loss One third of residents have lost more muscle strength and muscle mass than age alone would account for.Pharmazeutische Zeitung
28 weeks strength training works at 70 too In a German study of men aged 70 and over, sarcopenia status improved after 28 weeks with two sessions a week, while it got worse in the control group.Assmann-Stiftung, study summary
Figure 2 · Four areas

Where things shift with age — and what of that can be measured

Muscle loss does not stand on its own. Four areas feed into one another, and in each there are values that change before anything is noticed.

Area 1 Muscle and tissue The loss affects not just strength but the supporting structure: connective tissue, tendons and bone lose substance at the same time.
—Less muscle means lower energy turnover — and so an imbalance sooner on the same diet.
—Muscle is the body's largest store of amino acids. As it shrinks, the reserve for illness is missing.
—Strength training works at any age. In a German study of men aged 70 and over, status improved after 28 weeks with two sessions a week.
Measurable: the 18 amino acids in Prevent 360, including leucine — the building block that triggers muscle protein synthesis.
Area 2 Uptake in the gut With age, stomach acid declines, and with it the uptake of several nutrients. Medicines add to this.
—Vitamin B12 needs stomach acid and intrinsic factor. With atrophic gastritis, or on proton pump inhibitors or metformin, uptake falls.
—Iron is taken up better in an acidic environment — here too, less acid works against you.
—The gut flora changes; diversity falls with little exercise and a monotonous diet.
Measurable: B12, homocysteine and folic acid from blood, methylmalonic acid from urine, microbiome and digestive performance from stool.
Area 3 Nutrients and amino acids Requirements rise, intake often falls — less appetite, smaller portions, less variety.
—Vitamin D forms more slowly in older people's skin, and they are outdoors less often.
—With a confirmed vitamin D deficiency below 30 ng/ml, supplementation is recommended; for giving it without a deficiency, the evidence in sarcopenia is missing.
—For leucine there are indications that supplementation increases muscle mass — indications, not a firm recommendation.
Measurable: vitamin D in the vitamin check and in Prevent 360, minerals intracellularly in the whole blood mineral analysis.
Area 4 Sleep, neurotransmitters The share of deep sleep falls with age, and tissue repair happens in deep sleep. Every kind of recovery therefore slows down.
—Melatonin is formed from serotonin, and so from tryptophan — the chain needs vitamin B6, iron and magnesium.
—If cortisol stays high in the evening, sleep shifts into the lighter stages.
—The neurotransmitter profile and the daily cortisol profile complement the nutrient analysis here.
Measurable: serotonin, dopamine, GABA in the neurotransmitter profile; cortisol three times a day in the daily profile.
Figure 3 · Protein spread

Not more protein in the evening, but spread evenly through the day

Muscle protein synthesis is triggered per meal, not per day. About 25 to 30 grams of protein per meal is enough for that — more at once adds nothing here. Two days with the same daily total can therefore work out very differently.

Evenly spread 84 g am Tag
28 g Breakfast
28 g Midday
28 g Evening
Schwelle 25 g
Threshold met three timesMuscle protein synthesis is stimulated at every meal.
Evening only 84 g am Tag
10 g Breakfast
14 g Midday
60 g Evening
Schwelle 25 g
Threshold met only onceThe same daily amount, but two meals stay below the threshold. Anything beyond about 30 grams does not raise synthesis further at this point.

For older people the professional bodies recommend 1.0 to 1.2 grams of protein per kilogram of body weight a day, and up to 1.5 with chronic illness — considerably more than the 0.8 grams named in the past. This does not apply where kidney function is impaired; a doctor then sets the amount.

Putting it in context

What is measured and what is still open

A lot is promised on this subject. So here, kept apart: what is established, what there are indications for, and what stays open.

Evidenced Strength training, protein Strength training combined with enough protein is the best-evidenced intervention against muscle loss in older age. No supplement replaces it.Deutsches Ärzteblatt 2025; ESPEN recommendations
Evidenced Vitamin D with a confirmed deficiency Below 30 ng/ml, supplementation is recommended. A study in people who had fallen found better leg function on the monthly reference dose; higher doses brought no advantage and came with more falls.Urologie in der Praxis 2023; Deutsches Ärzteblatt 2025
Hinweise Leucin, Omega-3, Kreatin For leucine there are indications of an increase in muscle mass. In a study with fish oil, participants walked faster, but muscle strength did not rise. Creatine is well studied in strength sport, less so in older age.Deutsches Ärzteblatt 2025; healthandscience.eu
Offen NAD precursors and biological age Supplements with NAD precursors are widely marketed; solid evidence that they slow ageing is missing. We do not offer a test that produces an age figure. Our epigenetic analyses produce something else: DNA stability, inflammation factors, micronutrients and stress-associated miRNAs.Chubanava & Treebak, Free Radical Biology and Medicine 2023
Quellen
  1. Diagnostik und Therapie der Sarkopenie und sarkopenen Adipositas, Deutsches Ärzteblatt 2025 — KORA-Age prevalence, vitamin D, leucine.
  2. Sarkopenie: Wenn die Muskeln schwinden, Pharmazeutische Zeitung — rates of loss, anabolic resistance, InCHIANTI study.
  3. Optimierte Ernährung bei Sarkopenie, Schweizer Zeitschrift für Ernährungsmedizin — leucine threshold, 25 to 30 g protein per meal.
  4. Sarkopenie unter dem Brennglas, FETeV 2026 — protein 1.0 to 1.5 g/kg, vitamin D, omega-3.
  5. Muskelgesundheit und Ernährung im Alter, Urologie in der Praxis 2023 — vitamin D dosage and risk of falls.
  6. Sarkopenie – wenn die Muskeln im Alter schwinden, Assmann-Stiftung — strength training from 70, 28 weeks.
  7. Chubanava S, Treebak JT, Free Radical Biology and Medicine 2023 — NAD precursors less effective than training.
Questions and answers

Common questions

Free initial consultation

Why measure at all, if decline is normal?

Because the difference between normal decline and sarcopenia only becomes visible once strength is gone. Nutrient levels shift earlier, and at that point they can be measured.

A broad stocktake tells you where you stand. A second measurement, at the earliest after three months, tells you whether anything has shifted.

Which test is the right place to start?

Prevent 360, with 75 parameters from a single sample. It covers nutrients, amino acids, inflammation markers, metabolic values, hormones and neurotransmitters.

If digestion, bloating or frequent infections are an issue, the gut microbiome test adds to it. For sleep problems, the neurotransmitter profile and the daily cortisol profile. If you want to start small, take the whole blood mineral analysis.

Why does vitamin B12 come up so often with age?

Absorption needs stomach acid and intrinsic factor. Both decline with age, and proton pump inhibitors or metformin add to that.

The blood value on its own tells you little about whether B12 reaches the cell. Methylmalonic acid in the organic acids profile does that: it rises when B12 is missing there. Holo-transcobalamin, also mentioned in the literature, is not available from us as a self-test — a medical practice can measure it, so raise it with our expert network.

How much protein, and when?

For older people, the professional societies recommend 1.0 to 1.2 grams per kilogram of body weight per day, and up to 1.5 with chronic illness — clearly more than the 0.8 grams cited in the past.

What matters is the spread: around 25 to 30 grams per meal stimulates muscle protein synthesis most. This does not apply with reduced kidney function; there a doctor sets the amount.

Can a supplement slow down ageing?

We make no statement on that. What is established is that strength training and enough protein slow muscle loss. For supplements: worthwhile where a deficiency has been shown, and without one, usually with no evidence of benefit.

We do not offer a test that returns a biological age number. Our epigenetic tests measure DNA stability, inflammatory factors, micronutrients and stress-associated miRNAs — which is something different. What a value means, and whether a supplement is worth considering, is something to discuss with our expert network.

Your Partner in Health

All the figures come from studies and describe groups, not individual cases. Unintended weight loss, repeated falls or strength that drops away quickly should be looked into at a medical practice.