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Intolerances

When your stomach swells after a meal.

Bloating, pressure in the upper abdomen, diarrhoea, headaches, and in children restlessness and trouble concentrating. If symptoms keep coming after certain meals, it is worth looking at histamine, lactose, fructose and gluten.

You take the sample at home. A partner laboratory evaluates it. You discuss the lab report with a doctor or a non-medical practitioner.

Two people at a laid breakfast table, a half-empty plate with bread, cheese and fruit
Analysen

Two tests that make sense for most people

Which one fits depends on what you have noticed. The guide below matches observations to methods.

01 · Beschwerden

Why it often goes unnoticed

With an intolerance, symptoms do not always appear straight away. Hours or even days can pass between the meal and the reaction. That is why the link to food often goes unnoticed.

In the gut

Wind and a bloated stomach

Pressure or cramps after eating

Diarrhoea or changing stools

Nausea

In the head

Headaches through to migraine

Grogginess after meals

Concentration drops off

Sleep gets more restless

On the skin

Redness on the face and neck

Itching

Hives

Known skin problems getting worse

In children

Tummy ache with no clear trigger

Irritability in the afternoon

Restlessness at school

poor sleep

These symptoms can have many causes. A test shows values, not a diagnosis. A doctor or a non-medical practitioner puts them in context.

02 · Hintergrund

Histamine: intake, breakdown, excess

Histamine is a messenger substance the body makes itself, and it is also in many foods, above all matured and fermented ones. It is broken down mainly in the gut by the enzyme diamine oxidase, DAO for short.

Step 01

Absorption

Histamine reaches the gut through matured and fermented foods: mature cheese, red wine, sauerkraut, smoked fish, salami.

Step 02

Breakdown by DAO

In the gut lining, the enzyme diamine oxidase breaks histamine down before it reaches the bloodstream. A second enzyme, HNMT, works inside the cells.

Step 03

When more arrives than is broken down

If the breakdown capacity is not enough, the histamine level rises. It is a matter of quantity, not a yes-or-no question: the same person tolerates more on one day than on another.

Step 04

Complaints

Histamine acts on blood vessels, the digestive tract and the nervous system. That is why flushing, headache, diarrhoea and palpitations appear in the same picture.

What can slow the breakdown

Low DAO activity, whether inherited or temporary

An irritated gut lining, where DAO is produced

Alcohol, which slows the breakdown and contains histamine itself

Certain medicines that block DAO

Large amounts at once: several histamine-rich dishes in one meal

What is measured

DAO activity in serum

Histamine in stool

Histamine in blood

Zonulin and alpha-1 antitrypsin for the gut barrier

Also: vitamin B6, copper and zinc, which take part in the breakdown

There is no single lab value that proves histamine intolerance, and no agreed cut-offs. The values are one building block alongside a symptom diary and a dietary history. The condition itself is also judged differently across the specialist literature.

03 · Unterschiede

Histamine, lactose, fructose, gluten

Four different mechanisms, four different methods. The symptoms resemble each other; the causes do not.

ThemaWhat lies behind itTypical reaction timeVerfahren
Histamine Breakdown by the enzyme DAO is not enough for the amount taken in 20 minutes to several hours DAO in serum, histamine in stool or blood
Laktose The enzyme lactase does not fully split milk sugar 30 minutes to 2 hours H2 breath test, plus a genetic test
Fruktose The small intestine absorbs only a limited amount of fructose one to several hours H2-Atemgastest
Gluten / coeliac Autoimmune reaction to gluten, damaging the small intestine lining gradual, often over months Transglutaminase antibodies in blood, work-up by a doctor
IgG to foods Antibodies against food components; the significance is disputed among experts not clearly assignable IgG measured from blood, up to 270 foods

Reaction times are rough guides, not fixed rules. Coeliac disease is an autoimmune condition, not an intolerance; a suspected case belongs with a doctor, and antibody testing only means something while gluten is still being eaten.

04 · Kinder

With children it looks different

Children rarely describe stomach trouble precisely. Instead of “I feel unwell after eating”, it shows as restlessness, irritability, poor sleep or slipping concentration at school. The link to food is then easy to miss.

Because children and parents share the same household and, in part, the same gut flora, symptoms often turn up in several people. A joint test puts the values side by side.

Other words

Children say "I feel funny", not "I have bloating".

Other signs

Restlessness, irritability and tiredness instead of clear tummy trouble.

Smaller samples

Stool and urine are straightforward, breath testing from about age six.

Never without cause

Analyses in children only where there is a specific observation.

To ORY Family Balance — 10 % from three tests →
05 · Wegweiser

Which test fits which observation?

A guide, not a recommendation. If you are unsure, sort it out in the free initial consultation.

After milky coffee or yoghurt the stomach swells up

Symptoms usually come within two hours and depend on the amount.

Laktose-Atemgastest

Fruit, dried fruit or soft drinks cause trouble

The small intestine absorbs fructose only to a limited degree; the rest ferments in the large bowel.

Fruktose-Atemgastest

Red wine, cheese or salami lead to flushing and headache

A typical histamine pattern: several systems react at once.

Histamine and DAO testing

Symptoms with no recognisable pattern, spread over the day

Here a broader look at gut flora and gut barrier helps more than a single test.

Microbiome with leaky gut markers

Persistent symptoms, tiredness, weight loss

This needs a doctor's assessment first, before a self-test makes sense.

Medical assessment, then coeliac testing

Several people in the family have similar symptoms

Values placed side by side show more than a single measurement.

Family Balance, from three tests
06 · Analysen

The tests at a glance

Price and sample type are on every card. We are happy to work out which one fits you beforehand.

Result ready 7–21 days after the sample reaches the laboratory.

07 · Ablauf

How it works

01

Choose an analysis

Pick by what you noticed, or clear it up in the first consultation.

02

Kit arrives by post

With instructions, request form and return envelope.

03

Take the sample at home

Follow the preparation; for breath tests, start fasting.

04

Review lab report

The result is in the Evi app. Then book an appointment.

What a lab report means for you comes from a doctor or a non-medical practitioner, not from this page.

These tests do not replace a medical examination. With acute symptoms, contact a doctor. Do not cut foods out permanently on your own — a needlessly restricted diet can itself lead to deficiencies, especially in children.

Common questions

Common questions about intolerances

What is the difference between an allergy and an intolerance?

With an allergy, the immune system reacts to a protein in the food, usually within minutes to a few hours. With an intolerance, an enzyme is missing or weak, or a substance is poorly absorbed. The reaction is slower, often only after hours, and depends on the amount. That is why many people tolerate small portions without trouble.

How can I tell that food is behind it?

By the repetition. Keep a simple diary for two weeks: what, when, how much, and which symptoms followed and when. If a pattern emerges, that is the best starting point for an analysis and for the conversation.

How is histamine measured?

The usual options are DAO activity in blood, histamine in stool and histamine in blood. Each of these values has its limits: there is no single conclusive test and no agreed cut-off values. The values are looked at together with what you have noticed, not on their own.

Why is the breath test the standard for lactose and fructose?

Because it measures directly what happens in the gut. You drink a defined amount of lactose or fructose. If the sugar is not absorbed in the small intestine, bacteria in the large intestine break it down, producing hydrogen that is breathed out through the lungs. If the breath value rises clearly above the fasting value, that points to an intolerance.

Can I do the breath test at home?

Yes. You get the test solution, the tubes and a timetable. You breathe into the first tube while fasting, drink the solution and repeat at fixed intervals over about two to three hours. The tubes then go to the laboratory together.

What does a food IgG test tell you?

It measures IgG antibodies against food components. Whether raised IgG values cause symptoms is disputed among specialists: several allergy societies consider the test unsuitable for diagnosing an intolerance, because IgG is also found in people with no symptoms. In functional practice it is nonetheless used as a pointer for a temporary elimination phase. You should know this before you order.

What does the gut lining have to do with it?

The gut barrier has a say in what passes from the gut into the body. Markers such as zonulin and I-FABP are used to gauge barrier function. Histamine is also broken down largely in the gut lining. That is why, with persistent symptoms, both are often looked at: intolerance and gut status.

Is there anything to do before the test?

Yes, and it decides how meaningful the result is. For breath tests: fast for at least twelve hours, and avoid gassy or high-fibre foods the day before. If coeliac disease is suspected, gluten must not be left out beforehand, or the test comes back falsely negative. Certain medicines affect the DAO measurement. The exact notes are included with every kit.

From what age are the tests suitable for children?

Stool and urine samples are straightforward from toddler age. Breath tests require the child to breathe out into a tube in a controlled way, which usually works from about six. A fingertip blood sample is possible from four, but should be talked through with the child. If in doubt, settle it beforehand in the initial consultation.

Should I cut out foods permanently if a value stands out?

No, not on your own and not permanently. An unnecessarily restricted diet can itself lead to deficiencies, especially in children. A value that stands out is a reason for a conversation, in which the elimination phase, its length and reintroduction are planned.

How long does it take to get the result?

The result is ready 7 to 21 days after the sample arrives at the laboratory. The lab report is then available in the Evi app. Evi stores and displays; a human does the interpretation.

What if the analysis comes back normal?

That happens, and it is useful information. Complaints after eating can also come from the amount, the speed, the make-up of a meal, from stress or from the gut flora. Gut analyses or a different angle are then the sensible next step.