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The histamine that accumulates in the intestine and has not been broken down is excreted in the stool.

The cause of an elevated histamine concentration in the stool can be, among other things, the consumption of histamine-rich foods, but also a food allergy, increased stress, or impaired histamine breakdown. The term histaminosis describes the condition: "too much histamine in the body." In histamine intolerance, the cause lies in a histamine breakdown disorder.

What exactly happens during a histamine and DAO enzyme analysis – biomarker measurement?

Many people suffer from nonspecific complaints whose causes often go undetected – histamine intolerance is one of them. This test will help you shed light on the situation: Are you sensitive to histamine-containing foods? Does your body produce enough DAO enzyme? This combined analysis will finally give you clarity – for greater well-being and targeted therapy.

What should be avoided?

Histamine is naturally present in some plant-based foods. However, there are also products that only become rich in histamine through processing, preservation, or ripening processes (lactic acid fermentation). This is due to microorganisms that have the ability to convert the amino acid histidine into histamine.

FAQs

Please read our FAQs page to find out more.

What does the histamine level in the stool indicate?

Regularly measuring histamine in the stool also allows for a reliable assessment of the success of an elimination diet. Simultaneous determination of DAO activity and histamine in the stool provides important differential diagnostic clues for distinguishing histamine intolerance from food allergy.

How can you diagnose histamine intolerance?

The most common symptoms of histamine intolerance are: Skin: Sudden redness ("flush"), rash, hives, itching. Gastrointestinal: Bloating, abdominal pain, diarrhea, nausea, vomiting. Respiratory: Blocked or runny nose, asthma. It measures the histamine level in the stool and the enzyme diamine oxidase (DAO) in the blood – two important markers if histamine intolerance is suspected.

What causes histamine in the gut?

Histamine can cause various reactions in the intestines, especially in those with histamine intolerance. Histamine is a chemical compound that occurs naturally in the body and plays an important role in the immune system and allergic reactions. In the digestive system, histamine can increase the production of gastric acid and increase the activity of muscle cells in the lining of the gastrointestinal tract. This can lead to symptoms such as abdominal pain or cramps, diarrhea, and bloating. These symptoms are typical of histamine intolerance, in which the body has difficulty effectively breaking down histamine, leading to a buildup and the unpleasant reactions described.

How do you know that your intestinal flora is affected?

A disturbed or "broken" intestinal flora can actually manifest itself through a variety of symptoms, primarily affecting the digestive tract. Some of the most common signs of a disturbed intestinal flora are:
Digestive problems: These include symptoms such as diarrhea, constipation, bloating, and abdominal pain. These problems can arise from an imbalance of good and bad bacteria in the gut.
Nausea and cramps: Disturbed intestinal flora can impair normal digestion and lead to nausea or cramps.
Increased susceptibility to infections: A healthy intestinal flora helps strengthen the immune system. Impaired intestinal flora can lead to increased susceptibility to infections.
Altered mood and energy: Studies have shown that gut health can also influence psychological aspects such as mood and energy, as the gut plays an important role in the production of certain neurotransmitters.
Allergies and intolerances: A disturbed intestinal flora can also lead to increased sensitivity to allergens or food intolerances.
If symptoms like these occur, especially after antibiotic therapy, which can affect the intestinal flora, it is advisable to consult a doctor. The doctor may recommend tests to assess the extent of the disturbance and take appropriate measures to restore the intestinal flora, for example, through probiotics or an adapted diet.

How is histamine broken down?

Diamine oxidase (DAO) breaks down histamine in the small intestine, thus preventing histamine from food from being absorbed into the body.

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