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Präzise und zuverlässige Diagnosetests bequem zu Hause durchführen

Individuelle Ganzheitliche Diagnostik

Ursachen erkennen, Potenzial entfalten, für deine innere Balance und Regeneration.

Why is the product useful?

The activity of β-glucuronidase directly influences hormone levels and the body's detoxification capacity. An imbalance can promote diseases such as endometriosis, hormone-dependent tumors, or metabolic disorders. The analysis can be used to target interventions—for example, through diet, probiotics, or medication.

What if symptoms are ignored?

An unbalanced enzyme level can lead to:

Permanent hormone imbalance

Incorrect medication effects (e.g. prodrugs, contraceptives)

Increased toxin return to the body
This can contribute to metabolic, cardiovascular or hormone-dependent diseases in the long term

Discover physiological effects

β-Glucuronidase is an enzyme produced by certain bacteria in the intestines and plays a key role in hormonal balance and detoxification. It can reactivate previously excreted substances such as estrogens, medications, or toxins in the intestines and transport them back into the body.

A permanently elevated β-glucuronidase level can lead to hormone re-poisoning and increase the risk of conditions such as PMS, endometriosis, chronic inflammation or hormone-dependent tumors.
Its counterpart is glucuronidation – an important detoxification pathway in the liver that makes substances water-soluble and prepares them for excretion. If this mechanism is disrupted by overactive β-glucuronidase, it can manifest itself in a variety of ways: hormonal imbalances, mood swings, skin problems, headaches, or chronic fatigue.

By analyzing β-glucuronidase in the stool, you can determine whether your intestinal hormone metabolism is in balance – and whether your excretory processes are working as they should.
This gives you important clues about hidden hormonal imbalances before they become clinically visible.

Publikationen

(1) Wang L. et al. Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening: a meta-analysis. BMC Gastroenterol. 2022.

(2) Yue C. et al. Meta-Analyses on SDC2 Gene Methylation. Front Med (Lausanne). 2022.

(3) Boyu Q. et al. Real-World retrospective study in China. 2024.

(4) Zhao S. et al. Real-World SDC2 Methylation Screening Study. Gastroenterology. 2024.

FAQs

Please read our FAQs page to find out more.

Why should I do the ß-glucuronidase test at all?

Beta-glucuronidase regulates whether toxins and hormones are excreted or reactivated. Excessive activity can, for example, release estrogens back into the body—which can lead to hormonal imbalances or chronic inflammation in the long term. For symptoms such as PMS, endometriosis, exhaustion, or digestive problems, it's worth taking a look at this key enzyme of the microbiome.

What can I actually do with the ß-glucuronidase test results?

Measuring beta-glucuronidase levels reveals whether your gut is reactivating certain substances too strongly or too weakly. An elevated level can cause hormonal overload or toxin reabsorption, while a low level can impair medication effectiveness. The test is therefore an essential component for targeted interventions in functional medicine, detox therapy, and hormone regulation.

How does this test relate to my long-term health?

Beta-glucuronidase acts directly on the enterohepatic circulation and thus on your hormonal self-regulation. If it is imbalanced, the long-term risk of metabolic disorders, hormone-dependent tumors, or chronic diseases increases. Early detection allows you to take targeted countermeasures – for more balance, self-efficacy, and healthy aging.

What does the ß-glucuronidase test measure? And how often should I take the test?

The concentration of the enzyme ß-glucuronidase in the stool – relevant for detoxification and hormone regulation.

Who is the test suitable for?
For people with hormonal problems, planned hormone or detox therapy, or suspected microbiome imbalance.

How often should I take the test?
For existing complaints or treatments, every 6–12 months. For preventative purposes, it's also useful annually.

Is the test reliable?
Yes – it is carried out in specialized partner laboratories under the highest standards.

Can I discuss the results with my doctor?
Of course – you can discuss the findings with doctors, alternative practitioners, or our ORY experts.

Does the health insurance company cover the costs?
Currently, this is a self-pay service. Some private insurers may reimburse a portion of the costs—please check with your individual provider.

Who is the test suitable for?

For people with hormonal issues, planned hormone or detox therapy, or suspected microbiome imbalance. For existing issues or treatments, every 6–12 months. Annually is also recommended for preventative purposes.

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