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Epigenetik

Epigenetic analyses measure methylation patterns on the DNA — not the genes themselves, but the way they are read. From these patterns the laboratory calculates figures on cell ageing, metabolism and strain.

All four analyses run on capillary blood from the fingertip. The results are a snapshot, not a diagnosis. What a value means is something you discuss with a practitioner.

Grundlage

What epigenetic analyses measure

The gene sequence stays the same for life. What changes is the marking on the DNA — and that responds to age, diet, exercise, sleep and strain.

Look up biomarkers
01 Sample 120 µl of capillary blood from the fingertip, taken at home.
02 Methylation pattern The laboratory reads where methyl groups sit on the DNA.
03 Key figures From the patterns the laboratory calculates values, on cell ageing for example.
04 Making sense of it The lab report comes digitally. What it means for you is settled in a conversation.
What these analyses are not Not a genetic test and not a statement about the risk of illness. The gene sequence is not read. An epigenetic age is a figure taken from methylation patterns, not a medical finding — it does not replace a medical assessment.
Scientific background

The text stays, the bookmarks move

A gene only takes effect when it is read. Where a stretch carries many methyl groups it lies quiet — the sequence itself is unchanged.

Schematic, not to scale
Stretch active · little methylation READING IN PROGRESS · GENE PRODUCT FORMS
Stretch quiet · densely methylated READING BLOCKED · NO GENE PRODUCT
Methyl group at a CpG site DNA strand, sequence unchanged
What shapes the pattern Methylation patterns shift over years. Links have been described with age, diet, exercise, sleep, smoking and long-term strain.
Age The strongest link described. Patterns shift over decades.
Diet Methyl groups are built from components that come from food.
Exercise Differences between trained and untrained people are described in muscle and blood cells.
Sleep Too little sleep and shift work go along with altered patterns.
Smoking One of the best-documented influences, with typical sites in the pattern.
Long-term strain Sustained psychological strain is linked in studies with changes in the pattern.
When a stretch is not read

What a blockage means for the metabolism

If the stretch is densely methylated, the protein it stands for is not made — and everything built on it is missing further down the chain.

01 → Stretch densely methylated Reading factors find no way in; the chromatin lies packed tight.
02 → No messenger RNA Without reading, no copy is made to leave the cell nucleus.
03 → Protein missing The enzyme or transport protein it stands for is not made.
04 → Metabolic step stalls Whatever this enzyme should convert builds up in front of it.
05 Non-specific symptoms Exhaustion, concentration, recovery — rarely traceable to one cause.

Methylation is not a fault but a control: in every cell most of the genome is switched off on purpose, otherwise a liver cell could not be a liver cell. It only becomes a problem when a stretch lies quiet that would be needed.

What healthy methylation needs Building blocks and conditions
Folate, B12, B6 and choline These form S-adenosylmethionine, the methyl group donor.
Protein containing methionine Methionine is the precursor of the donor and comes from food.
Exercise Different patterns are described in the muscle and blood cells of trained people.
Sleep in rhythm Regular sleep goes along with steadier patterns.
Relief from constant stress Sustained strain is linked with changes in the pattern.
Vegetables and plant compounds For individual substances, effects on the enzymes involved are described, mostly in the laboratory.
What goes along with unfavourable patterns in studies Strains and gaps
Smoking The best-documented influence, with typical altered sites.
Alcohol Interferes with folate and methionine metabolism.
Folate and B12 deficiency Without the building blocks, methylation cannot be kept up.
Chronic inflammation Inflammatory signals go along with altered patterns in immune cells.
Excess weight, high blood sugar For both, links with methylation patterns are described.
Pollutants Effects are described for heavy metals and some environmental pollutants.

The links named here come from observational studies and basic research. They do not describe what any single intervention does for you and do not replace a medical assessment.

Kit to lab report

How an epigenetic analysis works

Timing starts when the sample reaches the lab
01 → Order The kit is posted out or collected at the practice. Dispatch the next working day
02 → Sample at home 120 µl of capillary blood from the fingertip, as instructed. About ten minutes
03 → Return A postage-paid envelope is enclosed; post Monday to Thursday. Postage is paid
04 → Laboratory The DNA is prepared and methylation is measured at defined sites. Partner laboratory in Germany
05 → Calculation From the pattern the laboratory calculates the figures of the model used. 7–21 days from arrival of the sample
06 Lab report and conversation The lab report comes digitally, with a results consultation. PDF and app
Why before therapy Your constitution as a starting point
A baseline before the first change, to compare against later on.A second measurement after six to twelve months shows the direction.The figures add to blood and stool results; they do not replace them.
What the lab report does
Give figures for one point in time, from defined sites in the methylation pattern.Make changes visible over longer periods, when the same method is repeated.Put numbers behind a conversation with a practitioner.
What it does not do
Not a genetic test: the DNA sequence is not read.No statement about disease risk and no diagnosis.No comparison between laboratories or models — different models give different figures.
Darmvorsorge

ColoSafe · stool test you do at home

A stool test that looks for markers in stool which can occur with bowel cancer and certain precursor stages. An abnormal result is not a diagnosis — it is a reason to see a doctor.

1 Test

This test does not replace a colonoscopy, nor the statutory bowel cancer screening. If you have symptoms, the work-up belongs in a doctor's hands, whatever the test result.

Abdominal complaints, bloating or intolerances?Overview: stomach and digestion
Preparations

From this area

Five preparations around cell energy, gut flora and nutrient supply. Whether one of them is right for you, and in what amount, is something you discuss with a practitioner after the lab report.

5 Präparate

Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. Do not exceed the recommended daily intake.

Several preparations on one theme, 5 % cheaper than bought singly.View packages
Questions and answers

Common questions on epigenetics

Is this a genetic test?

No. The gene sequence is not read. What is measured are the methyl groups sitting on the DNA, which the body uses to control which sections get read.

So the result tells you nothing about inherited traits, and it is no statement about the risk of illness.

What is epigenetic age?

A figure the laboratory calculates from the methylation patterns and compares with your calendar age.

It is a value from a model, not a medical finding. Different laboratories and models arrive at different numbers.

Do I need a doctor for the analysis?

No. We send you the test set, or you collect it at the practice. Sample collection is designed for home.

If you have symptoms, whether acute or long-standing, it makes sense to have them looked at by a doctor as well.

How long does the evaluation take?

7 to 21 days from when the sample reaches the lab, not from your order.

You will be notified by e-mail as soon as the lab report is ready. Every analysis comes with a results consultation.

How often is it worth repeating?

Methylation patterns change slowly. Leave at least six months between two measurements, better twelve.

Measured sooner, it is hard to tell whether a change is real or lies within the spread of the method.

What ColoSafe does and what it does not

The stool test looks for markers that can occur with bowel cancer and certain precursors. An abnormal result is a reason for medical assessment.

It does not replace a colonoscopy or the statutory screening programme. A normal result does not rule out disease.

To take away

What to take away

  1. 01 It is not a genetic test The DNA sequence is not read. What is measured is what sits on the DNA and steers how it is read.
  2. 02 Epigenetic age is a calculated value It comes from a model, not from an examination. Other laboratories and models arrive at other figures.
  3. 03 One value on its own says little The use comes from the comparison: once now, once after six to twelve months, with the same method.
  4. 04 Patterns change slowly Any sooner than six months and a real change cannot be told apart from the scatter of the method.
  5. 05 No statement about disease risk And no diagnosis. If you have symptoms, have them checked by a doctor — whatever the result.
  6. 06 ColoSafe does not replace a colonoscopy An abnormal result is a reason to see a doctor; a normal one rules nothing out.
QuellenJones MJ, Goodman SJ, Kobor MS, DNA methylation and healthy human aging, Aging Cell (2015).Horvath S, Raj K, DNA methylation-based biomarkers and the epigenetic clock theory of ageing, Nature Reviews Genetics (2018).Joehanes R et al., Epigenetic signatures of cigarette smoking, Circulation: Cardiovascular Genetics (2016).
Your Partner in Health

Food supplements are not a substitute for a balanced, varied diet and a healthy lifestyle.