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Skin health

The skin and the gut lining are both boundary surfaces with a microbiome of their own, and both depend on the same immune state. What happens at one often shows up at the other.

So what we measure here is not the skin itself but what acts on it from the inside: the gut barrier, histamine and its breakdown, the building materials and the hormone axis.

Analysen

What is measured here

10 Analysen · €55 bis €518
Histamine stool test – Figure 1 of 4 Stuhl
HistamineThe histamine value on its own — the cheapest way in when redness or itching appears shortly after eating.
1 MarkerStuhl
€55,00 Ansehen
Whole Blood Mineral Analysis – Figure 1 of 5 Kapillarblut
VollblutmineralanalyseZinc, selenium, iron and copper inside the cell. Zinc is part of the work-up for acne, copper is a cofactor of DAO.
Zinccopperintracellular
€75,00 Ansehen
Omega-3/6 Test - Fatty Acid Analysis – Figure 1 of 3 Kapillarblut
Omega-3-IndexEPA, DHA, linoleic acid and the ratios — the fatty acids the skin barrier is partly built from.
EPADHAQuotienten
€90,00 Ansehen
Histamine and DAO Enzyme Analysis – Biomarker Measurement – Figure 1 of 3 Stool and blood
Histamine and DAOHistamine in stool and the activity of diamine oxidase in blood — the substance and the enzyme that breaks it down.
Histamine (stool)DAO (blood)
€93,00 Ansehen
Vitamin Check Basic – Figure 1 of 3 Kapillarblut
Vitamin Check BasicVitamin D, B12, E, folic acid and coenzyme Q10.
Vitamin DB12E
€98,50 Ansehen
Daily Cortisol Profile – Figure 1 of 5 Speichel
Cortisol-TagesprofilCortisol in the morning, at midday and in the evening, plus DHEA. Strain is a described factor in the course of atopic dermatitis and psoriasis.
3 MesspunkteDHEA
€155,00 Ansehen
Women's hormone profile – Figure 1 of 4 Speichel
Hormone Profile WomenOestradiol, progesterone, testosterone and DHEA — the axis at issue in acne that follows the cycle.
OestradioltestosteroneDHEA
€160,05 Ansehen
Leaky Gut + Absorption – Figure 1 of 3 Stuhl
Leaky Gut & AbsorptionThe barrier itself: zonulin, alpha-1 antitrypsin, sIgA and bile acids.
sIgAzonulinα1 antitrypsin
€179,90 Ansehen
Intestinal profile microbiome, leaky gut mucosa check – Figure 1 of 5 Stuhl
Gut microbiome analysisComposition and diversity of the gut flora, digestive performance and the markers of the gut lining.
Microbiomezonulincalprotectin
€315,00 Ansehen
Acne basic profile Stool and blood
Acne Basic ProfileThe broad route: gut bacteria, nutrients and hormones in one go.
Stool and bloodbroad
€518,00 Ansehen
Figure 1 · Four factors

What acts on the skin from inside

Four areas that the specialist literature regularly links with skin conditions. For each one, we say what of it we can actually measure.

Factor 1 Gut and barrier The gut lining and the skin are both boundary surfaces with a microbiome of their own. What happens at one shows up at the other — in the specialist literature this goes under the gut-skin axis.
—What has been shown are associations, not simple chains of cause and effect. An abnormal barrier value does not explain a skin condition on its own.
—The two named most often are rosacea and atopic dermatitis.
—What is measured is the boundary surface, not the skin: sIgA, zonulin, calprotectin and the composition of the flora.
Measurable: Leaky Gut & Absorption for the barrier, gut microbiome analysis for the flora.Reviews of the gut-skin axis
Factor 2 Histamine and DAO Histamine widens blood vessels and irritates nerve endings — which produces redness, weals and itching. It comes from mast cells, from food and from gut bacteria.
—It is broken down in the gut wall by diamine oxidase, which needs vitamin B6 and copper.
—The timing in relation to meals is often the most useful clue.
—Histamine intolerance is established clinically, not from a single lab value.
Measurable: histamine on its own (stool) or together with DAO activity in blood.Literature on histamine intolerance
Factor 3 Nutrients and structure Skin is built and constantly renewed. For that it needs building material: zinc for wound healing, fatty acids for the barrier, vitamin A for keratinisation, vitamin C for the formation of collagen.
—The authorised claims cover normal function: zinc, vitamin A and biotin contribute to the maintenance of normal skin, vitamin C to normal collagen formation.
—These are not statements that a supplement improves a skin condition.
—What is missing in your case is what the lab report shows.
Measurable: zinc, selenium, iron and copper in the whole blood mineral analysis, vitamins D and E in the Vitamin Check, the fatty acids in the Omega-3 Index. We do not have vitamin A, vitamin C or biotin as a home test — a medical practice can measure them, so ask our expert network about it.Regulation (EU) No 432/2012, authorised claims
Factor 4 Hormones and stress Androgens drive sebum production, cortisol the readiness to inflame. Both axes act on the same glands — which is why skin conditions change with the cycle, with puberty and with strain.
—With acne in adults, the hormone axis is part of the work-up, particularly where the cycle is irregular.
—Lasting stress shifts the immune state and is linked with flare-ups of atopic dermatitis and psoriasis.
—The daily cortisol profile shows whether the curve still has its shape — a single value does not.
Measurable: Hormone Profile Women for the axis, the daily cortisol profile for strain.Reviews of stress and skin conditions
Figure 3 · Age groups

The same four factors, weighted differently

All four areas play a part at every age, but not to the same degree. The bars show where an investigation usually starts — not what is going on in your case.

Gut and barrier Histamine Nutrients Hormones and stress
0 to 12 years Kind The barrier and reactions to food come first here. Atopic dermatitis usually starts in the first years of life.
Gut and barrier
85
Histamine
60
Nutrients
70
Hormones and stress
15
Usually first: the Gut Check-up for children and Vitamin Check Basic for children and adolescents — this age group has its own test kits.
13 to 25 years Puberty and young adulthood Sebum production rises under androgens. Zinc is part of the work-up, and the hormone axis comes first.
Gut and barrier
50
Histamine
40
Nutrients
65
Hormones and stress
90
Usually first: the hormone profile and whole blood minerals for zinc.
26 to 45 years Erwachsenenalter Often a mixture: cycle, strain and diet act together. Acne in adults mostly affects women.
Gut and barrier
70
Histamine
65
Nutrients
70
Hormones and stress
80
Usually first: Prevent 360 as a stocktake and the daily cortisol profile — or the Acne Basic Profile, which brings together gut, nutrients and hormones.
ab 46 Jahren The menopause and after Oestrogen falls, and with it the water content and collagen density of the skin. Structure and building material move to the front.
Gut and barrier
55
Histamine
45
Nutrients
90
Hormones and stress
75
Usually first: whole blood mineral analysis, omega-3 index and hormone profile.

The weighting is a guide to the order of testing and comes from how often the areas are named in reviews for each age group. It is not a statement about any individual case. Where skin findings are unclear, dermatology decides.

Figure 2 · Histamine

Three sources, one enzyme

Histamine widens blood vessels and irritates nerve endings — which produces redness, weals and itching, often shortly after eating. It comes from three directions and is broken down in one place.

Its sources
From mast cells Released on irritation, allergy or mechanical pressure
From food Matured cheese, red wine, sauerkraut, fish that is not fresh
From gut bacteria Some species form histamine in the gut itself
DAO in the gut wall Diamine oxidase breaks histamine down. To do so it needs vitamin B6 and copper as cofactors.
What reaches the skin
Redness and flushing Vessels widen, the skin becomes warm and red
Weals Fluid moves into the tissue and raised patches form
Itching Histamine irritates the nerve endings in the skin directly
Measurable here
Histamine in stool Shows what is excreted through the gut. Our test works from stool, not from blood — the blood value varies a lot with the last meal.
DAO activity in blood Shows the capacity to break histamine down. A low value makes an intolerance more likely but does not prove it. Read together with the histamine value it carries weight; on its own it does not.
Vitamin B6 and copper The enzyme's cofactors. If they are missing, DAO works more slowly, whatever the amount of enzyme. Copper is in the whole blood mineral analysis and in OM Vital, vitamin B6 in Prevent 360.
What a lab value cannot do here Histamine intolerance is established clinically — from the symptoms, a limited period of avoidance and a controlled reintroduction. The lab value supports that route; it does not replace it.
about 1 % estimated frequency of histamine intolerance The figure comes from the specialist literature and is given as an estimate, because there is no single test that proves it. Women are affected more often.Specialist literature on histamine intolerance
clinically, not in the lab how the diagnosis is made From the symptoms, a period of avoidance and a controlled reintroduction — supported by a practitioner from our expert network.Approach set out by the professional bodies
60 to 80 % share of women among adults with acne Acne in adults mostly affects women; the figures in reviews are of this order.Reviews of acne tarda
Quellen
  1. Reviews of the gut-skin axis and of its link with rosacea and atopic dermatitis.
  2. Regulation (EU) No 432/2012 — authorised claims for zinc, vitamins A and C and biotin for skin and mucous membranes.
  3. Specialist literature on histamine intolerance: DAO activity, cofactors, diagnostic approach.
  4. Reviews of mental stress and the course of atopic dermatitis and psoriasis.
  5. Reviews of acne tarda and the role of androgens and SHBG.
Questions and answers

Common questions

Free initial consultation

Does my skin really have to do with my gut?

Both are boundary surfaces with a microbiome of their own, and both are shaped by the same immune state. In the specialist literature this connection is known as the gut–skin axis.

What has been shown are associations, not simple chains of cause and effect. An abnormal barrier value does not explain a skin condition on its own — it is one part of the picture our expert network puts together.

How is histamine linked to skin problems?

Histamine widens blood vessels and irritates nerve endings. That brings redness, weals and itching — often shortly after eating, which makes the link easier to spot.

We can measure histamine in stool and the activity of DAO, the enzyme that breaks it down, in blood. Histamine intolerance itself is established clinically: from symptoms, an elimination phase and a controlled reintroduction.

Which nutrients have authorised claims for skin?

Zinc contributes to the maintenance of normal skin, as do vitamin A and biotin. Vitamin C contributes to normal collagen formation for the normal function of skin.

These are statements about normal function, not claims that a supplement improves a skin condition. Of these, we measure zinc ourselves; vitamin A, C and biotin can be tested at a medical practice — ask our expert network about it.

Why does age matter for testing?

Because the emphasis shifts. In puberty, sebum production driven by androgens is at the front; from the menopause onwards it is the structure of the tissue as oestrogen falls.

The chart on this page is a guide to the order of testing, not a statement about any individual case. Where skin findings are unclear, dermatology decides.

Does this replace the dermatologist?

No. These tests give you measured values with the laboratory's reference range. A skin diagnosis is made by a doctor.

Skin lesions that change, bleed, grow or fail to heal need dermatological assessment at any age. The same goes for weals that appear suddenly with breathing difficulty — that is an emergency.

Your Partner in Health

All the figures come from studies and describe groups, not individual cases. Skin changes that alter, bleed, grow or fail to heal should be assessed by a dermatologist. Weals together with breathing difficulty are an emergency.