Organic acid

1. Comprehensive overview of metabolism

• Organic acids are intermediates and end products of numerous metabolic pathways, including carbohydrate, fat, and protein metabolism, as well as the citric acid cycle. The test shows whether these processes are functioning optimally or whether there are blockages or imbalances.
• The detection of certain acids in the urine can provide evidence of mitochondrial dysfunction, such as ineffective energy production, and other metabolic bottlenecks.

2. Detection of nutrient deficiencies

• Certain organic acids serve as biomarkers for vitamin and mineral deficiencies, especially for the B vitamins (e.g. xanthurenate for vitamin B6 and methylmalonate for vitamin B12).
• The test can detect signs of a deficiency, which could manifest as physical symptoms such as fatigue or difficulty concentrating, long before other blood tests show an abnormality.

3. Assessment of the gut microbiome

• Some organic acids, such as D-arabinitol and other specific metabolites, provide insights into the composition of the gut microbiome. An imbalance or overgrowth of certain microorganisms, such as Candida , can be revealed by elevated levels.
• The test can help detect dysbiosis (imbalance of intestinal flora), which is often associated with digestive problems, skin problems and immune disorders.

4. Identification of toxin exposure and detoxification problems

• Organic acids such as pyroglutamate and others provide insight into the body's detoxification capacity. High levels of certain acids can indicate toxin exposure or inefficient detoxification.
• The detoxification capacity is important because environmental toxins and metabolic waste products must be continuously excreted by the body.

5. Early detection of metabolic disorders

• The test can contribute to the early detection of certain metabolic disorders, such as mitochondrial dysfunction. Since mitochondria are responsible for energy production, disorders in this area could lead to chronic fatigue or muscle weakness.
• Early diagnosis can help with dietary adjustments and possible supplementation before major symptoms appear.

6. Support in the diagnosis of neurological and mental disorders

• Some organic acids, such as vanillinmandelic acid and homovanillinmandelic acid, are degradation products of neurotransmitters (dopamine, noradrenaline). Their presence and amounts can provide clues to neurotransmitter balance.
• The test can be helpful in diagnosing mood disorders, concentration problems, and even neurological diseases, as it indicates imbalances in neurotransmitter metabolism.

7. Simplicity and low invasiveness

• Compared to blood tests, the urine test is non-invasive and can be easily performed at home. It requires no needles or blood draw and is easy to collect and use.
• This test is a pleasant yet informative alternative, especially for children and patients who want to avoid frequent blood draws.

The urine organic acid test is a powerful diagnostic tool for assessing overall metabolic status and identifying potential deficiencies or imbalances. It provides comprehensive data that can serve as the basis for targeted nutritional and supplementation therapy, helping to support health naturally.

Lack of energy can also have mitochondrial causes , such as a lack of NAD due to activation or breakdown of the kynurenine pathway. This results in impaired ATP synthesis. Oxidative or nitrosative stress, triggered by stress-induced silent inflammation, can also cause mitochondrial dysfunction.