Welcome to our store

The ORY difference - Medical quality is our top priority.

Certified in laboratories

Use laboratory certification for superior product quality.

Developed by experts

Professionally developed products based on years of practical experience.

Scientifically sound

Perform precise and reliable diagnostic tests comfortably at home

Individual holistic diagnostics

Identify the causes, unlock your potential, for your inner balance and regeneration.

When is a Metabolom Plus test useful?

Chronic stress, severe pain, chronic inflammation, or microbiome changes can lead to shifts in metabolic pathways. This not only affects the production of important stress substances, but also produces metabolites that damage the organism, negatively impact mitochondria, or promote nitrosative stress.

Influence of stress

Inflammation caused by chronic stress affects serotonin and catecholamine synthesis through a disruption of tryptophan metabolism and the BH4 cycle. Increased consumption of these neurotransmitters under stress and impaired synthesis result in increasing neuron depletion. This creates a feeling of burnout, fatigue, and lack of energy.

Lack of energy can have mitochondrial causes

But neurostress isn't the only cause—low energy can also be due to mitochondrial causes, such as a lack of NAD due to activation or breakdown of the kynurenine pathway. This results in impaired ATP production. Oxidative or nitrosative stress, triggered by stress-related inflammation, can also cause symptoms.

Publications

(1) Wang L. et al. Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening: a meta-analysis. BMC gastroenterol. 2022.

(2) Yue C. et al. Meta-Analyses on SDC2 Gene Methylation. Front Med (Lausanne). 2022.

(3) Boyu Q. et al. Real-world retrospective study in China. 2024.

(4) Zhao S et al. Real-World SDC2 Methylation Screening Study. Gastroenterology. 2024.

FAQs

Please read our FAQs page to find out more.

What is special about this test?

* no travel to and from the doctor/alternative practitioner necessary
* easy handling
* Results within 7 to 14 days
* Notification by email as soon as the results are available
* 15-minute free evaluation and therapy recommendation
* if required ORY Health Coach Online

Which neurotransmitters are being studied?

Tryptophan, central kynurenine metabolites (e.g., kynurenine, kynurenic acid, 3-OH-kynurenine, quinolinic acid), NAD, serotonin, and calculated IDO/KMO activity indices; optionally catecholamines. Urine creatinine is used for normalization.

What is the benefit of a neurotransmitter test?

For people with fatigue, sleep/mood problems, stress, brain fog, or preventively within the framework of longevity, functional medicine, and holistic diagnostics.

What happens when neurotransmitters are missing?

A neurotransmitter deficiency can have profound effects on mental and physical health. Different neurotransmitters are responsible for different functions in the body, and a deficiency can lead to a variety of symptoms and disorders. Here are some specific effects that can be caused by a deficiency of individual neurotransmitters:
- Serotonin deficiency
Psychological symptoms: depression, anxiety, irritability, and mood swings.
Physical symptoms: sleep disturbances, changes in appetite, and migraines.
- Dopamine deficiency
Psychological symptoms: Reduced motivation, listlessness, depression and cognitive impairment.
Physical symptoms: Motor problems such as the movement disorders and muscle stiffness observed in Parkinson's disease.
- Noradrenaline deficiency
Symptoms: problems with attention and concentration, depressive moods, fatigue and sometimes orthostatic hypotension (low blood pressure when standing up).
- GABA deficiency
Symptoms: Increased anxiety, sleep problems, chronic stress reactions, and possibly seizures.
- Acetylcholine deficiency
Symptoms: Cognitive impairments such as memory loss, difficulty learning new information, and, in severe cases, symptoms associated with Alzheimer's disease.

These symptoms and disorders arise because neurotransmitters play key roles in the transmission of signals within the nervous system. A deficiency disrupts effective communication between nerve cells (neurons), which can lead to dysfunction in the body and behavior.

Treatments for neurotransmitter deficiencies may include medications aimed at increasing neurotransmitter levels or mimicking their action in the brain, as well as therapies and lifestyle changes that can help support and improve nervous system function.

Which neurotransmitters are missing in depression?

Yes. The report supports the doctor's consultation and helps to plan further diagnostics or therapy.

Didn't find your answer?

Don't hesitate to contact us

ORX experts. Between uncertainty and clarity lies only a conversation.

At ORY, we help you understand your questions – and find out which diagnostics or support is right for you.

Book an appointment now