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Professionally developed products based on years of practical experience.

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Perform precise and reliable diagnostic tests comfortably at home

Individual holistic diagnostics

Identify the causes, unlock your potential, for your inner balance and regeneration.

Biochemistry of melatonin

Many sleep problems remain invisible because they have functional causes. Melatonin is the central regulator of your sleep-wake cycle. A low melatonin level at night can contribute to difficulty falling asleep and staying asleep, daytime fatigue, and reduced regeneration. At the same time, melatonin influences immune function and acts as a free radical scavenger – relevant for cell health and healthy aging. The test shows whether your body reaches the expected melatonin peak at night. This provides you with an objective marker to more effectively manage measures such as light hygiene, evening screen time, nutrient status (e.g., tryptophan/B6/magnesium), stress and cortisol management, and sleep rituals. Ideal for shift workers or those experiencing jet lag, when the body's internal clock is disrupted. Those who think preventively can use the test for early diagnosis – before imbalances become entrenched. In short: more clarity, greater self-efficacy, and improved sleep quality.

What can I actually do with the results – what is the test good for?

The result shows whether your nighttime melatonin level is within the target range. If there are deviations, you can derive evidence-based steps: light management (bright in the morning, dark in the evening), blue light reduction, sleep timing (chronotype), sleep environment (cool, quiet), nutrition (precursors & cofactors), stress reduction (breathing, HRV routines), and – after consulting a doctor – melatonin-related interventions. Melatonin is produced from serotonin/tryptophan and follows a circadian regulation (suprachiasmatic nucleus, light impulses). Saliva measurement close to the biological peak provides a practical assessment of nighttime production. In functional medicine, melatonin serves as a causal marker for sleep and regeneration issues, which can be linked to cortisol rhythm, microbiome, silent inflammation, and nutrient status. With ORY you receive a clearly presented report with actionable next steps – for real change instead of helplessness.

How does this test relate to my long-term health, prevention, and self-healing?

Healthy aging means stabilizing rhythms: Sleep is the foundation for regeneration of the brain, immune system, hormones, and metabolism. An adequate melatonin peak is key. The test helps identify early warning signs, address functional weaknesses, and activate self-healing through sleep-promoting routines. Strengthening your circadian axis reduces oxidative stress, supports detoxification processes, and promotes cellular resilience. In combination with evi.plus and optional expert guidance, an individualized health roadmap is created. This fosters trust in your own body – and allows you to consciously, holistically, and sustainably shape your path to health.

Publications

(1) Wang L. et al. Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening: a meta-analysis. BMC gastroenterol. 2022.

(2) Yue C. et al. Meta-Analyses on SDC2 Gene Methylation. Front Med (Lausanne). 2022.

(3) Boyu Q. et al. Real-world retrospective study in China. 2024.

(4) Zhao S et al. Real-World SDC2 Methylation Screening Study. Gastroenterology. 2024.

FAQs

Please read our FAQs page to find out more.

What does the test measure?

The free melatonin level in night saliva – it shows the actual nocturnal hormone production.

Who is the test suitable for?

For people with sleep disorders, shift work, jet lag, chronic stress or for prevention as part of a holistic health strategy.

How often should I take the test?

When used as directed, no side effects are known. If you experience any individual intolerances or allergies, discontinue use and consult a physician. This test is for analysis purposes only and is not intended to diagnose or treat any disease.

Is the test reliable?

The test should not be performed by persons under 18 years of age without adult supervision. If you have a serious medical condition, please consult a physician before performing the test. Individuals who are already under medical care or taking medications that may affect oxidative stress should consult their physician before using the test.

Can I take the result to my doctor?

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