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The histamine that accumulates in the intestine and has not been broken down is excreted in the stool.

The cause of an elevated histamine concentration in the stool can be, among other things, the consumption of histamine-rich foods, but also a food allergy, increased stress, or impaired histamine breakdown. The term histaminosis describes the condition: "too much histamine in the body." In histamine intolerance, the cause lies in a histamine breakdown disorder.

What exactly happens with a histamine intolerance?

Histamine plays important roles in the body, with excessive amounts of histamine leading to pseudo-allergic intolerance reactions in the nervous system, gastrointestinal, and respiratory tracts. It acts as an inflammatory mediator against harmful substances. Anyone who has come into contact with a stinging nettle knows the sensation: red, itchy, painful, and swollen.

Histamine Stool Test – When Your Body Goes into Overdrive

Elevated histamine levels can indicate histamine intolerance or a disorder in histamine breakdown. Histamine is an endogenous messenger substance involved in many processes, including immune reactions, digestion, and blood pressure regulation. However, if too much histamine is produced or too little is broken down, it can trigger various symptoms.

🔍 What does an elevated histamine level mean?
If the histamine level in stool is elevated, it indicates an overload of the histamine balance. This can be caused by:
• increased intake of histamine-rich foods,
• reduced activity of the DAO (diamine oxidase) enzyme, or
• bacterial overgrowth in the gut.

⚠️ Typical symptoms of histamine overload:
• Headaches or migraines
• Skin redness, itching, or hives
• Digestive problems (bloating, diarrhea, abdominal pain)
• Heart palpitations, dizziness, or circulatory problems
• Fatigue, inner restlessness, sleep disturbances

🍎 Foods with high histamine content – best to avoid:
• Aged cheese, salami, ham
• Sauerkraut, pickles
• Wine, beer, sparkling wine
• Canned fish, smoked fish
• Tomatoes, spinach, eggplants
• Chocolate, nuts

In addition, there are foods that release histamine in the body ("histamine liberators"), such as strawberries, citrus fruits, or certain spices. Reactions to these can vary individually.

🧬 Consider individual intolerances
Everyone reacts differently – in addition to general histamine levels, individual food intolerances can also play a role. An IgG food test can help uncover these personal reaction patterns and specifically adjust your diet.

FAQs

For more information, please see our FAQs.

What does the histamine level in the stool indicate?

Regularly measuring histamine in the stool also allows for a reliable assessment of the success of an elimination diet. Simultaneous determination of DAO activity and histamine in the stool provides important differential diagnostic clues for distinguishing histamine intolerance from food allergy.

How can you diagnose histamine intolerance?

The most common symptoms of histamine intolerance are: Skin: Sudden redness ("flush"), rash, hives, itching. Gastrointestinal: Bloating, abdominal pain, diarrhea, nausea, vomiting. Respiratory: Blocked or runny nose, asthma.

What causes histamine in the gut?

Histamine can cause various reactions in the intestines, especially in those with histamine intolerance. Histamine is a chemical compound that occurs naturally in the body and plays an important role in the immune system and allergic reactions. In the digestive system, histamine can increase the production of gastric acid and increase the activity of muscle cells in the lining of the gastrointestinal tract. This can lead to symptoms such as abdominal pain or cramps, diarrhea, and bloating. These symptoms are typical of histamine intolerance, in which the body has difficulty effectively breaking down histamine, leading to a buildup and the unpleasant reactions described.

How do you know if your intestinal flora is damaged?

A disturbed or "broken" intestinal flora can actually manifest itself through a variety of symptoms, primarily affecting the digestive tract. Some of the most common signs of a disturbed intestinal flora are:
Digestive problems: These include symptoms such as diarrhea, constipation, bloating, and abdominal pain. These problems can arise from an imbalance of good and bad bacteria in the gut.
Nausea and cramps: Disturbed intestinal flora can impair normal digestion and lead to nausea or cramps.
Increased susceptibility to infections: A healthy intestinal flora helps strengthen the immune system. Impaired intestinal flora can lead to increased susceptibility to infections.
Altered mood and energy: Studies have shown that gut health can also influence psychological aspects such as mood and energy, as the gut plays an important role in the production of certain neurotransmitters.
Allergies and intolerances: A disturbed intestinal flora can also lead to increased sensitivity to allergens or food intolerances.
If symptoms like these occur, especially after antibiotic therapy, which can affect the intestinal flora, it is advisable to consult a doctor. The doctor may recommend tests to assess the extent of the disturbance and take appropriate measures to restore the intestinal flora, for example, through probiotics or an adapted diet.

How is histamine broken down?

Diamine oxidase (DAO) breaks down histamine in the small intestine, thus preventing histamine from food from being absorbed into the body.

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