Vitamin B6

Vitamin B6 (pyridoxine) is a universal cofactor in more than 100 enzyme reactions – particularly for the synthesis of neurotransmitters (serotonin, dopamine, GABA) and for amino acid metabolism. A deficiency often shows itself as irritability, sleep disturbance and PMS. Included as an active marker in Prevent 360 and Neurotransmitter Plus.

How vitamin B6 acts in the body

In the liver, vitamin B6 is converted into pyridoxal 5'-phosphate (PLP), the active form. PLP binds amino acids temporarily and so allows them to be converted, broken down or turned into messengers: 5-hydroxytryptophan becomes serotonin, L-dopa becomes dopamine, glutamate becomes GABA, histidine becomes histamine. PLP is also needed for breaking down homocysteine to cysteine, for making haem and for releasing sugar from glycogen.

Low vitamin B6 – what happens in the body?

When little PLP is available, many of these steps slow down: less serotonin, dopamine and GABA are made, homocysteine is broken down to cysteine more slowly and can rise, and haem formation is slowed. In tryptophan metabolism, intermediates such as xanthurenic acid build up. Skin, mucous membranes (cracked corners of the mouth, inflamed tongue) and nerves are sensitive. Causes are low intake, alcohol, kidney disease and certain medications.

High vitamin B6 – what happens in the body?

Very high levels arise almost only from high-dose intake over a long period. The sensory nerves can then be damaged – with tingling, numbness and unsteady gait, usually in the hands and feet. When the high intake stops, the symptoms usually recede.

The interpretation is given in your report.