HLA-DQ2 / HLA-DQ8 (coeliac predisposition)

HLA-DQ2 and HLA-DQ8 are variants of immune genes. They are analysed in EDTA blood; as a genetic test, written consent is required.

What HLA-DQ2 and DQ8 do in the body

HLA molecules sit on immune cells and present protein fragments to the immune system. DQ2 and DQ8 bind fragments of gluten particularly tightly – especially after the enzyme transglutaminase 2 has modified them. This activates T cells in the small-intestinal lining; in coeliac disease it leads to inflammation and flattening of the villi.

HLA-DQ2 or DQ8 detected – what does it mean?

A positive result shows the genetic prerequisite for coeliac disease. Many people carry DQ2 or DQ8 without ever developing it – the result alone is therefore not an indication of existing coeliac disease. Whether it is present is shown by transglutaminase antibodies and, if necessary, a small-intestinal tissue sample.

Neither HLA-DQ2 nor DQ8 – what does it mean?

If both features are absent, coeliac disease is considered very unlikely in the medical literature. Other reactions to wheat, such as wheat allergy or wheat sensitivity, are not covered by the genetic test.

The interpretation is given in your report.