Transglutaminase 3 antibodies (anti-TG3)
Transglutaminase 3 (TG3, epidermal transglutaminase) is an enzyme of the outer skin. The test measures IgA antibodies against TG3 in serum.
What TG3 does in the body
TG3 cross-links proteins of the horn cells and makes the outermost skin layer resilient. In people with coeliac-type gluten intolerance, the immune system can form antibodies against TG3. When these are deposited in the skin together with the enzyme, inflammation with intensely itchy blisters develops, dermatitis herpetiformis Duhring.
Raised anti-TG3 – what does it mean?
Raised antibodies indicate a gluten-related immune reaction involving the skin. Dermatitis herpetiformis is confirmed by a skin tissue sample; the treating practice clarifies this.
Low anti-TG3 – what does it mean?
A low value shows no antibody formation against TG3.
The interpretation is given in your report.
Also known as: anti-tg3, tg3, epidermal transglutaminase, dermatitis herpetiformis
Contexts in which this value is measured
- Itching
- Blisters on the skin
- Skin rash
Analyses that include this value
There is currently no analysis in the shop for this value. A practitioner or doctor from the ORY expert network can tell you how else it can be determined.
View the expert networkReference ranges and how your personal value is to be read are set out in your findings report. You discuss the findings with a practitioner or doctor from the ORY expert network.