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testosterone deficiency symptoms, measuring free testosterone, SHBG testosterone, DHEA men, low testosterone causes, testosterone deficiency diagnostics, men’s health hormones laboratory, ORY Analysis testosterone

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Tiredness, muscle loss, no interest in sex, low mood — many men know this combination and call it stress or age. But behind these symptoms there is often a measurable hormone deficiency. Urologie am Ring and current science show: testosterone has been falling across the population for decades — and not only because of age.

Kategorie:

Hormones and men’s health. Topic: testosterone, SHBG, free testosterone, DHEA. Suitable for: newsletter and blog, ory-berlin.de, week 19 / May 2026

In this article you will learn which 10 signs point to low testosterone, why total testosterone alone is not enough, and which laboratory values really count.

A 30-year-old today statistically has less testosterone than a 30-year-old did 30 years ago. Not an isolated case, not a coincidence — but a population-wide trend documented in science since the 1980s and continuing to this day.

In their video “5 natürliche Mittel für mehr Testosteron”, Urologie am Ring explains what men can do themselves. The second video, “10 Anzeichen, dass Dir Testosteron fehlt”, makes clear how many men already know the symptoms — without knowing what lies behind them.

But before we come to remedies, it is worth looking at what testosterone actually is and what happens when it is missing.

How testosterone acts in the body

Testosterone is far more than a sex hormone. It regulates muscle mass, bone density, fat distribution, energy metabolism, mood, concentration and heart health.

About 95 per cent is produced in the testes and considerably smaller amounts in the adrenal glands. In the blood, around 98 per cent of testosterone is bound — to SHBG (sex hormone-binding globulin) and albumin — and in this form is biologically inactive.

Only free testosterone, about 2 per cent of the total value, acts directly in the cells. So anyone who knows only their total testosterone value knows only half the story. DHEA, the precursor hormone produced in the adrenal glands, supplies the raw material for testosterone and oestrogen and falls continuously after the age of 25 — to around a third of the starting value by the age of 60.

What happens when testosterone is too low

Urologie am Ring describes ten signs that point to testosterone deficiency and that are often attributed to age or stress: persistent tiredness and listlessness despite enough sleep, loss of libido and erectile problems, muscle loss alongside an increase in abdominal fat, depressive moods and irritability, problems with concentration and memory, sleep problems, loss of bone density, and a general feeling of no longer being your old self.

Particularly insidious: many of these symptoms develop so slowly that those affected accept them as normal — as an unavoidable part of growing older. They are not necessarily that.

What happens when testosterone stays too high

Chronically raised testosterone — usually through uncontrolled external intake — is likewise problematic.

It suppresses the body’s own hormone production, increases the formation of oestradiol through aromatisation, and can cause acne, hair loss, aggression and, in the long term, cardiovascular risks. The natural upper limit is not an arbitrary laboratory value — it reflects the physiological balance of a complex hormone system.

Anyone supplementing testosterone without knowing the whole axis risks more than they gain.

Did you know…

…a meta-analysis published in Springer Nature in 2025, which evaluated 1,064,891 men from studies between 1971 and 2024, confirms a significant, age-independent decline in testosterone levels in the male population — with a decrease of up to one per cent per calendar year, in addition to the normal age-related decline?

Environmental factors such as endocrine disruptors from pesticides, plastics and plasticisers are considered partly responsible, but this has not yet been conclusively proven. Falling sperm quality, rising rates of overweight and lack of sleep also play a documented role.

Andrew Huberman, neuroscientist at Stanford University, puts the clinical consequence in a nutshell: “Free testosterone — not the total value — is what counts. And sleep, nutrition and stress management come before any therapy.” Peter Attia adds: “An SHBG value without free testosterone is clinically worthless. Anyone who knows only the total value does not know whether their hormone is working at all.”

Which values really matter

A complete male hormone status profile covers several levels. First, total testosterone as a starting value — ideally measured in the morning between 7 and 10 a.m., since the level fluctuates by up to 30 per cent over the course of the day.

Second, SHBG, to understand how much testosterone is actually bound and therefore inactive. Third, free testosterone, calculated or measured directly — the clinically relevant share. Fourth, DHEA-S as a long-term marker of adrenal capacity and hormone reserve. In addition LH and FSH, which show whether the deficiency originates in the testes or in the control by hypothalamus and pituitary.

Oestradiol and prolactin belong to this as well — raised oestradiol inhibits testosterone directly, raised prolactin can point to an adenoma. Zinc and vitamin D round off the picture, since both are directly involved in testosterone synthesis.

Why ORY Analysis makes the difference here

In standard medicine testosterone is measured — if at all — as a single value. SHBG, free testosterone, DHEA and LH are almost always missing from a routine blood count.

ORY Analysis records the complete male hormone profile: total and free testosterone, SHBG, DHEA-S, oestradiol as well as the relevant micronutrients zinc and vitamin D. The result is not an isolated laboratory value but an overall picture — interpreted, explained clearly and accompanied by concrete recommendations for action. Anyone who knows where they stand can act deliberately. Anyone who guesses loses time.

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Sources

  1. Springer Nature (2025): „Temporal trends in serum testosterone and luteinizing hormone levels indicate an ongoing resetting of hypothalamic-pituitary-gonadal function in healthy men: a systematic review." Journal of Endocrinological Investigation. https://link.springer.com/article/10.1007/s40618-025-02671-9
  2. PMC (2025): „Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives." PMC ID: 12841019. https://pmc.ncbi.nlm.nih.gov/articles/PMC12841019/
  3. PubMed (2020): „Secular trends in testosterone – findings from a large state-mandate care provider." PubMed ID: 32151259. PMC: 7063751. https://pubmed.ncbi.nlm.nih.gov/32151259/
  4. Urologie am Ring (2019): „5 natürliche Mittel für mehr Testosteron." YouTube. https://www.youtube.com/watch?v=I474oz3Uv_0
  5. YouTube (2025): „10 Anzeichen, dass Dir Testosteron fehlt." https://www.youtube.com/watch?v=u2dcAGl1CH4
  6. Huberman, Andrew (2022): „The Science of How to Optimize Testosterone & Estrogen." Huberman Lab Podcast. Stanford University. https://www.hubermanlab.com/episode/the-science-of-how-to-optimize-testosterone-and-estrogen
  7. Attia, Peter; Gifford, Bill (2023): Outlive – The Science and Art of Longevity. New York: Harmony Books.
  8. Gesundheitsinstitut Sundao: „DHEA, SHBG & Estradiol – die vergessenen Männerhormone." https://www.gesundheitsinstitut-sundao.de/post/dhea-shbg-estradiol-die-vergessenen-m%C3%A4nnerhormone

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In this article you will learn which 10 signs point to testosterone deficiency, why the total testosterone value alone is not enough and which measured values really count.